Wednesday, 4 June 2008

renal transplantation

exam question:
patient with renal transplant and arteriovenous fistula,did not had palpable kidneys.
what are the causes of renal failure?
discussion about polycystic kidney disease(presentation/complications)

Polycystic kidney disease:
AD chromosome 16
Prevalence 1:1000
The third most common cause of CRF in the UK

see presentation below.
what are the most used immunosuppresive medications and its saide effects?

18 comments:

  1. long-term drug treatment for the prevention of rejection is employed in all cases apart from living related donation from an identical twin.
    -Corticosteroids
    -Azathioprine
    Adverse effects include suppression of red cell and platelet production, an increased incidence of infections (particularly viral), and hepatotoxicity.
    other side effects:
    hypersensitivity reactions,dose-related bone marrow suppression,liver impairment, cholestatic jaundice and hair loss.
    -Ciclosporin
    Its introduction has revolutionized organ transplantation. Disadvantages include high cost and nephrotoxicity.
    other side effects:
    gastro-intestinal disturbances, gingival hyperplasia, hepatic dysfunction, anorexia; hypertension; tremor and headache.
    -Tacrolimus
    calcineurin inhibitor
    Its side-effects are broadly similar to those of CSA except it is more diabetogenic
    -Sirolimus
    synergistic with CSA but lack nephrotoxicity
    Its main side-effects are thombocytopenia and hyperlipidaemia.

    ReplyDelete
  2. complications of renal transplant:
    1-opportunistic infections
    2-premature coronary artery disease
    3-hypertention
    4-lymphoma/skin cancer
    5-glumerulonephritis
    6-complications of steroid therapy

    ReplyDelete
  3. complications of APKD:
    renal complications:
    1-lion pain
    2-anaemai
    3-polycythemia
    4-hypertension
    5-renal failure
    extrarenal complications:
    cystic: cysts in other organs (liver, ovary,pancreas,spleen)
    non-cystic:SAH,MVP
    GIT:colonoic diverticulae

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